Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases.

ABSTRACT:

Background

Human plasma contains a wide variety of circulating proteins. These proteins can be important clinical biomarkers in disease and also possible drug targets. Large scale genomics studies of circulating proteins can identify genetic variants that lead to relative protein abundance.

Methods

We conducted a meta-analysis on genome-wide association studies of autosomal chromosomes in 22,997 individuals of primarily European ancestry across 12 cohorts to identify protein quantitative trait loci (pQTL) for 92 cardiometabolic associated plasma proteins.

Results

We identified 503 (337 cis and 166 trans) conditionally independent pQTLs, including several novel variants not reported in the literature. We conducted a sex-stratified analysis and found that 118 (23.5%) of

SUBMITTER: Carland C 

PROVIDER: S-EPMC10405520 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature