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Advances in translating mGlu₂ and mGlu₃ receptor selective allosteric modulators as breakthrough treatments for affective disorders and alcohol use disorder.

ABSTRACT: Metabotropic glutamate (mGlu) receptors are promising targets for the treatment of affective disorders and alcohol use disorder (AUD). Nonspecific ligands for Group II (mGlu₂ and mGlu₃) mGlu receptors have demonstrated consistent therapeutic potential for affective disorders in preclinical models. Disentangling the specific roles of mGlu₂ versus mGlu₃ receptors in these effects has persisted as a major challenge, in part due to pharmacological limitations. However, the recent development of highly specific allosteric modulators for both mGlu₂ and mGlu₃ receptors have enabled straightforward and rigorous investigations into the specific function of each receptor. Here, we review recent experiments using these compounds that h

SUBMITTER: Tyler RE

PROVIDER: S-EPMC10405528 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Advances in translating mGlu₂ and mGlu₃ receptor selective allosteric modulators as breakthrough treatments for affective disorders and alcohol use disorder.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Advances in translating mGlu2 and mGlu3 receptor selective allosteric modulators as breakthrough treatments for affective disorders and alcohol use disorder.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Advances in translating mGlu₂ and mGlu₃ receptor selective allosteric modulators as breakthrough treatments for affective disorders and alcohol use disorder.