Anti-VEGF therapy selects for clones resistant to glucose starvation in ovarian cancer xenografts.

ABSTRACT:

Background

Genetic and metabolic heterogeneity are well-known features of cancer and tumors can be viewed as an evolving mix of subclonal populations, subjected to selection driven by microenvironmental pressures or drug treatment. In previous studies, anti-VEGF therapy was found to elicit rewiring of tumor metabolism, causing marked alterations in glucose, lactate ad ATP levels in tumors. The aim of this study was to evaluate whether differences in the sensitivity to glucose starvation existed at the clonal level in ovarian cancer cells and to investigate the effects induced by anti-VEGF therapy on this phenotype by multi-omics analysis.

Methods

Clonal populations, obtained from both ovarian cancer cell lines (IGROV-1 and SKOV3) and tumor xenografts upon glucose deprivation

SUBMITTER: Boso D 

PROVIDER: S-EPMC10405561 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature