Parvovirus B19 DNA and antibodies in Chinese plasma donors, plasma pools and plasma derivatives.

ABSTRACT:

Background

Human parvovirus B19 (B19V) is a common contaminant found in plasma pools and plasma derivatives. Previous studies were mainly focused on limited aspects, further assessment of prevalence of B19V DNA and antibodies in plasma donors, the contamination of B19V in pooled plasma and plasma derivatives should be performed in China.

Study design and methods

Individual plasma donors' samples from four provinces and pooled plasma from four Chinese blood product manufacturers were collected and screened using B19V DNA diagnostic kits between October 2018 and May 2020. The positive samples were investigated for the seroprevalence of B19V antibodies and subjected to sequence analysis and alignment for phylogenetic studies. Moreover, 11 plasma donors who were B19V DNA-positiv

SUBMITTER: Sun P 

PROVIDER: S-EPMC10405795 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature