Senescent melanocytes driven by glycolytic changes are characterized by melanosome transport dysfunction.

ABSTRACT: Rationale: Senescent melanocytes accumulate in photoaged skin and are closely related to skin aging. A better understanding of the molecular characteristics of senescent melanocytes may be the key to controlling skin aging. Methods: We have developed an in vitro model of senescence in melanocytes using UV irradiation and investigated the functional characteristics and molecular mechanisms underlying senescence in UV-irradiated melanocytes. Results: We have highlighted that in vitro senescent melanocytes are characterized by melanosome transport dysfunction resulting in melanin accumulation. The defective melanosome transport was confirmed with the ultrastructural characterization of both in vitro UV-induced senescent melanocytes and in vivo

SUBMITTER: Park YJ 

PROVIDER: S-EPMC10405833 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature