Theranostics in the vasculature: bioeffects of ultrasound and microbubbles to induce vascular shutdown.

ABSTRACT: Ultrasound-triggered microbubbles destruction leading to vascular shutdown have resulted in preclinical studies in tumor growth delay or inhibition, lesion formation, radio-sensitization and modulation of the immune micro-environment. Antivascular ultrasound aims to be developed as a focal, targeted, non-invasive, mechanical and non-thermal treatment, alone or in combination with other treatments, and this review positions these treatments among the wider therapeutic ultrasound domain. Antivascular effects have been reported for a wide range of ultrasound exposure conditions, and evidence points to a prominent role of cavitation as the main mechanism. At relatively low peak negative acoustic pressure, predominantly non-inertial cavitation is most likely induced, while higher peak negative

SUBMITTER: Padilla F 

PROVIDER: S-EPMC10405856 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature