Similarities in rotavirus vaccine viral shedding and immune responses in pairs of twins.

ABSTRACT:

Objectives

Intestinal rotavirus (RV) vaccine replication and host immune response are suggested to be affected by several factors, including maternal antibodies, breastfeeding history, and gut microbiome, which are thought to be similar in pairs of twins. The aim of this study was to determine whether viral shedding from the fecal RV vaccine strain Rotarix^® (RV1) and IgG and IgA responses to RV show similarity in pairs of twins.

Methods

Quantitative reverse transcription polymerase chain reaction specific to RV vaccine strain RV1 was used to monitor fecal RV1 viral shedding. RV IgG and IgA titers were measured using an in-house enzyme-linked immunosorbent assay. Fecal RV1 viral shedding and immune responses were compared between twins and singletons with mixed eff

SUBMITTER: Enya Y 

PROVIDER: S-EPMC10405898 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature