Aspartate and Acetate Fuel Gastrointestinal Stromal Tumors Beyond the Warburg Effect.

ABSTRACT: Metabolic reprogramming is closely linked to the tumorigenesis and drug resistance of gastrointestinal stromal tumors (GISTs). Mapping the metabolic orbit of GISTs is a prerequisite if intervention against the metabolic vulnerability of refractory GISTs is desirable.

Methods

A total of 43 patients with treatment-naïve GISTs who had undergone surgical resections were enrolled, on whom a metabolomics profile detected from surgical specimens was constructed based on the ¹H-nuclear magnetic resonance (NMR) platform. The mRNA and protein levels of GLUT1, HK2, ACSS2, and FASN were assayed. Dual-tracer ¹⁸F-FDG/11C-acetate PET imaging was introduced before surgery in 15 patients.

Results

¹H-NMR-based metabolomics revealed that GISTs were characterized

SUBMITTER: Lai YC 

PROVIDER: S-EPMC10406007 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature