The Diesel Exhaust in Miners Study (DEMS) II: Temporal Factors Related to Diesel Exhaust Exposure and Lung Cancer Mortality in the Nested Case-Control Study.

ABSTRACT:

Background

The Diesel Exhaust in Miners Study (DEMS) was an important contributor to the International Agency for Research on Cancer reclassification of diesel exhaust as a Group I carcinogen and subsequent risk assessment. We extended the DEMS cohort follow-up by 18 y and the nested case-control study to include all newly identified lung cancer deaths and matched controls (DEMS II), nearly doubling the number of lung cancer deaths.

Objective

Our purpose was to characterize the exposure-response relationship with a focus on the effects of timing of exposure and exposure cessation.

Methods

We conducted a case-control study of lung cancer nested in a cohort of 12,315 workers in eight nonmetal mines (376 lung cancer deaths, 718 controls). Controls were selected from work

SUBMITTER: Silverman DT 

PROVIDER: S-EPMC10406174 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature