Influence of N6-methyladenosine (m6A) modification on cell phenotype in Alzheimer's disease.

ABSTRACT:

Objective

Recent research has suggested that m6A modification takes on critical significance to Neurodegeneration. As indicated by the genome-wide map of m6A mRNA, genes in Alzheimer's disease model achieved significant m6A methylation. This study aimed to investigate the hub gene and pathway of m6A modification in the pathogenesis of AD. Moreover, possible brain regions with higher gene expression levels and compounds exerting potential therapeutic effects were identified. Thus, this study can provide a novel idea to explore the treatment of AD.

Methods

Differential expression genes (DEGs) of GSE5281 and GSE48350 from the Gene Expression Omnibus (GEO) database were screened using the Limma package. Next, the enrichment analysis was conducted on the screened DEGs. Moreover,

SUBMITTER: Ni P 

PROVIDER: S-EPMC10406241 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature