Translocator protein PET imaging in temporal lobe epilepsy: A reliable test-retest study using asymmetry index.

ABSTRACT:

Objective

Translocator protein (TSPO) targeting positron emission tomography (PET) imaging radioligands have potential utility in epilepsy to assess the efficacy of novel therapeutics for targeting neuroinflammation. However, previous studies in healthy volunteers have indicated limited test-retest reliability of TSPO ligands. Here, we examine test-retest measures using TSPO PET imaging in subjects with epilepsy and healthy controls, to explore whether this biomarker can be used as an endpoint in clinical trials for epilepsy.

Methods

Five subjects with epilepsy and confirmed mesial temporal lobe sclerosis (mean age 36 years, 3 men) were scanned twice-on average 8 weeks apart-using a second generation TSPO targeting radioligand, [¹¹C]PBR28. We evaluated the test-re

SUBMITTER: Mahmud M 

PROVIDER: S-EPMC10406252 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature