Automated seizure onset zone locator from resting-state functional MRI in drug-resistant epilepsy.

ABSTRACT:

Objective

Accurate localization of a seizure onset zone (SOZ) from independent components (IC) of resting-state functional magnetic resonance imaging (rs-fMRI) improves surgical outcomes in children with drug-resistant epilepsy (DRE). Automated IC sorting has limited success in identifying SOZ localizing ICs in adult normal rs-fMRI or uncategorized epilepsy. Children face unique challenges due to the developing brain and its associated surgical risks. This study proposes a novel SOZ localization algorithm (EPIK) for children with DRE.

Methods

EPIK is developed in a phased approach, where fMRI noise-related biomarkers are used through high-fidelity image processing techniques to eliminate noise ICs. Then, the SOZ markers are used through a maximum likelihood-based classifier

SUBMITTER: Banerjee A 

PROVIDER: S-EPMC10406253 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature