Synergistic photobiomodulation with 808-nm and 1064-nm lasers to reduce the β-amyloid neurotoxicity in the in vitro Alzheimer's disease models.

ABSTRACT:

Background

In Alzheimer's disease (AD), the deposition of β-amyloid (Aβ) plaques is closely associated with the neuronal apoptosis and activation of microglia, which may result in the functional impairment of neurons through pro-inflammation and over-pruning of the neurons. Photobiomodulation (PBM) is a non-invasive therapeutic approach without any conspicuous side effect, which has shown promising attributes in the treatment of chronic brain diseases such as AD by reducing the Aβ burden. However, neither the optimal parameters for PBM treatment nor its exact role in modulating the microglial functions/activities has been conclusively established yet.

Methods

An inflammatory stimulation model of Alzheimer's disease (AD) was set up by activating microglia and neuroblastoma wi

SUBMITTER: Zhang R 

PROVIDER: S-EPMC10406259 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature