Family history of substance use disorder and parental impulsivity are differentially associated with neural responses during risky decision-making.

ABSTRACT:

Background

Risky decision-making is associated with the development of substance use behaviors during adolescence. Although prior work has investigated risky decision-making in adolescents at familial high risk for developing substance use disorders (SUDs), little research has controlled for the presence of co-morbid externalizing disorders (EDs). Additionally, few studies have investigated the role of parental impulsivity in offspring neurobiology associated with risky decision-making.

Methods

One-hundred twenty-five children (28 healthy controls, 47 psychiatric controls with EDs without a familial history of SUD, and 50 high-risk children with co-morbid EDs with a familial history of SUD) participated in the Balloon Analog Risk Task while undergoing functiona

SUBMITTER: Aloi J 

PROVIDER: S-EPMC10406275 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature