Cortical and Subcortical Structural Abnormalities in Patients With Idiopathic Cervical and Generalized Dystonia.

ABSTRACT:

Objectives

In this study, we sought to investigate structural imaging alterations of patients with idiopathic dystonia at the cortical and subcortical levels. The common and specific changes in two subtypes of dystonia, cervical dystonia (CD) and generalized dystonia (GD), were intended to be explored. Additionally, we sought to identify the morphometric measurements which might be related to patients' clinical characteristics, thus providing more clues of specific brain regions involved in the mechanism of idiopathic dystonia.

Methods

3D T1-weighted MRI scans were acquired from 56 patients with idiopathic dystonia and 30 healthy controls (HC). Patients were classified as CD or GD, according to the distinct symptom distributions. Cortical thickness (CT) of 30 CD and 26 GD we

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10406292 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature