Association of hypothyroidism during pregnancy with preconception and early pregnancy exposure to ambient particulate matter.

ABSTRACT:

Background

Limited research has been conducted on the association between preconception exposure to ambient particulate matter (PM) and hypothyroidism. This study aimed to investigate the relationship between preconception PM exposure and hypothyroidism.

Methods

A retrospective case-control study at China-Japan Friendship Hospital was performed. Fine particulate matter (PM_2.5) and inhalable particulate matter (PM₁₀) were obtained from the China High Air Pollution Dataset. Buffer analysis methods were used to calculate the exposure of pregnant women to PM in a circular area of 250, 500, and 750 m in diameter at preconception and in early pregnancy. Logistic regression models were used to assess the relationship between PM and hypothyroidism. Odd ratios (

SUBMITTER: Sun Q 

PROVIDER: S-EPMC10406672 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature