Diesel exhaust exposure alters the expression of networks implicated in neurodegeneration in zebrafish brains.

ABSTRACT: Neurodegenerative diseases are a major cause of disability in the world, but their etiologies largely remain elusive. Genetic factors can only account for a minority of risk for most of these disorders, suggesting environmental factors play a significant role in the development of these diseases. Prolonged exposure to air pollution has recently been identified to increase the risk of Alzheimer's and Parkinson's diseases, but the molecular mechanisms by which it acts are not well understood. Zebrafish embryos exposed to diesel exhaust particle extract (DEPe) lead to dysfunctional autophagy and neuronal loss. Here, we exposed zebrafish embryos to DEPe and performed high throughput proteomic and transcriptomic expression analyses from their brains to identify pathogenic pathways induced by ai

SUBMITTER: Jami MS 

PROVIDER: S-EPMC10406705 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature