Localization and Registration of 2D Histological Mouse Brain Images in 3D Atlas Space.

ABSTRACT: To accurately explore the anatomical organization of neural circuits in the brain, it is crucial to map the experimental brain data onto a standardized system of coordinates. Studying 2D histological mouse brain slices remains the standard procedure in many laboratories. Mapping these 2D brain slices is challenging; due to deformations, artifacts, and tilted angles introduced during the standard preparation and slicing process. In addition, analysis of experimental mouse brain slices can be highly dependent on the level of expertise of the human operator. Here we propose a computational tool for Accurate Mouse Brain Image Analysis (AMBIA), to map 2D mouse brain slices on the 3D brain model with minimal human intervention. AMBIA has a modular design that comprises a localization module and

SUBMITTER: Sadeghi M 

PROVIDER: S-EPMC10406728 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature