Specific subsets of urothelial bladder carcinoma infiltrating T cells associated with poor prognosis.

ABSTRACT: Comprehensive investigation of tumor-infiltrating lymphocytes in cancer is crucial to explore the effective immunotherapies, but the composition of infiltrating T cells in urothelial bladder carcinoma (UBC) remains elusive. Here, single-cell RNA sequencing (scRNA-seq) were performed on total 30,905 T cells derived from peripheral blood, adjacent normal and tumor tissues from two UBC patients. We identified 18 distinct T cell subsets based on molecular profiles and functional properties. Specifically, exhausted T (T_Ex) cells, exhausted NKT (NKT_Ex) cells, Ki67⁺ T cells and B cell-like T (B-T) cells were exclusively enriched in UBC. Additionally, the gene signatures of T_Ex, NKT_Ex, Ki67⁺ T and B-T cells were significantly associ

SUBMITTER: Guo R 

PROVIDER: S-EPMC10406853 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature