Micro-nanofiber composite biomimetic conduits promote long-gap peripheral nerve regeneration in canine models.

ABSTRACT: Peripheral nerve injuries may result in severe long-gap interruptions that are challenging to repair. Autografting is the gold standard surgical approach for repairing long-gap nerve injuries but can result in prominent donor-site complications. Instead, imitating the native neural microarchitecture using synthetic conduits is expected to offer an alternative strategy for improving nerve regeneration. Here, we designed nerve conduits composed of high-resolution anisotropic microfiber grid-cordes with randomly organized nanofiber sheaths to interrogate the positive effects of these biomimetic structures on peripheral nerve regeneration. Anisotropic microfiber-grids demonstrated the capacity to directionally guide Schwann cells and neurites. Nanofiber sheaths conveyed adequate elasticity and

SUBMITTER: Dong X 

PROVIDER: S-EPMC10406865 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature