Association between increased anterior cingulate glutamate and psychotic-like experiences, but not autistic traits in healthy volunteers.

ABSTRACT: Despite many differences, autism spectrum disorder and schizophrenia spectrum disorder share environmental risk factors, genetic predispositions as well as neuronal abnormalities, and show similar cognitive deficits in working memory, perspective taking, or response inhibition. These shared abnormalities are already present in subclinical traits of these disorders. The literature proposes that changes in the inhibitory GABAergic and the excitatory glutamatergic system could explain underlying neuronal commonalities and differences. Using magnetic resonance spectroscopy (¹H-MRS), we investigated the associations between glutamate concentrations in the anterior cingulate cortex (ACC), the left/right putamen, and left/right dorsolateral prefrontal cortex and psychotic-like experien

SUBMITTER: Demler VF 

PROVIDER: S-EPMC10406950 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature