Predictive value of brain atrophy, serum biomarkers and information processing speed for early disease progression in multiple sclerosis.

ABSTRACT:

Introduction

Multiple sclerosis (MS) is a chronic autoimmune-mediated demyelinating disease of the central nervous system (CNS). A clinical presentation of the disease is highly differentiated even from the earliest stages of the disease. The application of stratifying tests in clinical practice would allow for improving clinical decision-making including a proper assessment of treatment benefit/risk balance.

Methods

This prospective study included patients with MS diagnosed up to 1 year before recruitment. We analyzed serum biomarkers such as CXCL13, CHI3L1, OPN, IL-6, and GFAP and neurofilament light chains (NfLs); brain MRI parameters of linear atrophy such as bicaudate ratio (BCR), third ventricle width (TVW); and information processing speed were measured using the Symb

SUBMITTER: Oset M 

PROVIDER: S-EPMC10407123 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature