Cell-free DNA as a potential biomarker for acute myocardial infarction: A systematic review and meta-analysis.

ABSTRACT:

Background

Tissue necrosis releases cell-free deoxyribonucleic acid (cfDNA), leading to rapid increases in plasma concentration with clearance independent of kidney function.

Aim

To explore the diagnostic role of cfDNA in acute myocardial infarction (AMI).

Methods

This systematic review and meta-analysis included studies of cfDNA in patients with AMI and a comparator group without AMI. The quality assessment of diagnostic accuracy studies-2 (QUADAS-2) tool was used, with AMI determined from the criteria of the original study. Standardised mean differences (SMD) were obtained using a random-effects inverse variance model. Heterogeneity was reported as I². Pooled sensitivity and specificity were computed using a bivariate model. The area under the curv

SUBMITTER: Tan E 

PROVIDER: S-EPMC10407200 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature