A Pilot Genome-Wide Association Study Identifies Novel Markers of Metabolic Syndrome in Patients with Psoriasis.

ABSTRACT:

Background

Recent studies have reported that psoriasis is associated with the development of metabolic syndrome. Genome-wide association studies have been used to discover gene variant markers that occur frequently in case group in relation to specific diseases.

Objective

The aim of the present study was to investigate the variants of specific genes involved in metabolic syndrome associated with psoriasis.

Methods

A total of 95 psoriasis patients were recruited and divided into two groups: one with metabolic syndrome (38 patients) and the other without (57 patients). After genotyping, imputation, and quality checking, the association between the several single nucleotide polymorphisms and metabolic syndrome in psoriasis was tested, followed by gene set enrichment anal

SUBMITTER: Oh SM 

PROVIDER: S-EPMC10407332 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature