Efficacy of single-dose oral secnidazole for the treatment of trichomoniasis in women co-infected with trichomoniasis and bacterial vaginosis: a post hoc subgroup analysis of phase 3 clinical trial data.

ABSTRACT:

Objectives

Bacterial vaginosis (BV) and trichomoniasis are the most common causes of vaginitis. Both infections are associated with increased risk of acquisition and transmission of HIV and other sexually transmitted infections as well as adverse reproductive health outcomes. Co-infection is common, with rates ranging from 60% to 80%. We evaluated the efficacy of single-dose oral secnidazole 2 g for the treatment of trichomoniasis in a subgroup of women co-infected with BV and trichomoniasis.

Design

Post hoc analysis of data from a phase 3 randomised, double-blind, placebo-controlled, delayed-treatment study.

Setting

10 centres in the USA.

Participants

Subgroup of women (aged ≥12 years) with a confirmed diagnosis of Trichomonas vaginalis and co-infection

SUBMITTER: Muzny CA 

PROVIDER: S-EPMC10407359 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature