Clonal composition and differentiation stage of human CD30⁺ B cells in reactive lymph nodes.

ABSTRACT:

Introduction

Normal CD30⁺ B cells represent a distinct B-cell differentiation stage with features of strong activation. We lack an in depth understanding of these cells, because they are not present in peripheral blood and are typically very rare in reactive lymphoid organs. CD30⁺ B cells have been discussed as a potential precursor population for the malignant CD30⁺ Hodgkin and Reed-Sternberg cells in classical Hodgkin lymphoma. As CD30⁺ B cells can be more numerous in some cases of reactive lymphadenitis, we aimed to characterize these CD30⁺ B cells in terms of their differentiation stage and clonal composition, also as a means to clarify whether such CD30⁺ B-cell populations may represent potential precursor lesio

SUBMITTER: Kuppers R 

PROVIDER: S-EPMC10407394 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature