Identification of the novel FOXP3-dependent T_reg cell transcription factor MEOX1 by high-dimensional analysis of human CD4⁺ T cells.

ABSTRACT: CD4⁺ T cells play a central role in the adaptive immune response through their capacity to activate, support and control other immune cells. Although these cells have become the focus of intense research, a comprehensive understanding of the underlying regulatory networks that orchestrate CD4⁺ T cell function and activation is still incomplete. Here, we analyzed a large transcriptomic dataset consisting of 48 different human CD4⁺ T cell conditions. By performing reverse network engineering, we identified six common denominators of CD4⁺ T cell functionality (CREB1, E2F3, AHR, STAT1, NFAT5 and NFATC3). Moreover, we also analyzed condition-specific genes which led us to the identification of the transcription factor MEOX1 in T_reg cells. E

SUBMITTER: Baßler K 

PROVIDER: S-EPMC10407399 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature