Strain and temperature dependent aggregation of <i>Candida auris</i> is attenuated by inhibition of surface amyloid proteins.

ABSTRACT: Candida auris is a multi-drug resistant human fungal pathogen that has become a global threat to human health due to its drug resistant phenotype, persistence in the hospital environment and propensity for patient to patient spread. Isolates display variable aggregation that may affect the relative virulence of strains. Therefore, dissection of this phenotype has gained substantial interest in recent years. We studied eight clinical isolates from four different clades (I-IV); four of which had a strongly aggregating phenotype and four of which did not. Genome analysis identified polymorphisms associated with loss of cell surface proteins were enriched in weakly-aggregating strains. Additionally, we identified down-regulation of chitin synthase genes involved in the synthesis of the

SUBMITTER: Malavia-Jones D 

PROVIDER: S-EPMC10407437 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature