Value of radiomics in differentiating synchronous double primary lung adenocarcinomas from intrapulmonary metastasis.

ABSTRACT:

Background

Distinguishing synchronous double primary lung adenocarcinoma (SDPLA) from intrapulmonary metastasis (IPM) of lung cancer has significant therapeutic and prognostic values. This study aimed to develop and validate a CT-based radiomics model to differentiate SDPLA from IPM.

Methods

A total of 153 patients (93 SDPLA and 60 IPM) with 306 pathologically confirmed lesions were retrospectively studied. CT morphological features were also recorded. Region of interest (ROI) segmentation was performed semiautomatically, and 1,037 radiomics features were extracted from every segmented lesion The differences of radiomics features were defined as the relative net difference in radiomics features between the two lesions on CT. Those low reliable (ICC <0.75) and redundant (r>0.

SUBMITTER: Han X 

PROVIDER: S-EPMC10407476 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature