Proteomics analysis of lung tissue reveals protein makers for the lung injury of adjuvant arthritis rats.

ABSTRACT: Lung injury is one of the common extra‑articular lesions in rheumatoid arthritis (RA). Due to its insidious onset and no obvious clinical symptoms, it can be easily dismissed in the early stage of diagnosis, which is one of the reasons that leads to a decline of the quality of life and subsequent death of patients with RA. However, its pathogenesis is still unclear and there is a lack of effective therapeutic targets. In the present study, tandem mass tag‑labeled proteomics was used to research the lung tissue proteins in RA model (adjuvant arthritis, AA) rats that had secondary lung injury. The aim of the present study was to identify the differentially expressed proteins related to RA‑lung injury, determine their potential role in the pathogenesis of RA‑lung injury and provide potential

SUBMITTER: Zhang PH 

PROVIDER: S-EPMC10407615 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature