Kartogenin-enhanced dynamic hydrogel ameliorates intervertebral disc degeneration via restoration of local redox homeostasis.

ABSTRACT:

Introduction

Over-activation of oxidative stress due to impaired antioxidant functions in nucleus pulpous (NP) has been identified as a key factor contributing to intervertebral disc degeneration (IVDD). While Kartogenin (KGN) has previously demonstrated antioxidant properties on articular cartilage against osteoarthritis, its effects on NP degeneration have yet to be fully understood.

Objectives

This study aimed to investigate the protective effects of KGN on nucleus pulpous cells (NPCs) against an inflammatory environment induced by interleukin (IL)-1β, as well as to explore the therapeutic potential of KGN-enhanced dynamic hydrogel in preventing IVDD.

Methods

NPCs were isolated from rat caudal IVDs and subjected to treatment with KGN at varying concentrations (rang

SUBMITTER: Tian X 

PROVIDER: S-EPMC10407629 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature