Evaluation of the antioxidant activity, genotoxic, and cytotoxic effects of the ethanolic leaves extract of Abutilon hirtum (Lam.) Sweet using in vitro assays.

ABSTRACT: Abutilon hirtum (Lam.) Sweet belongs to the Malvaceae family and is a perennial shrub commonly known as Indian mallow, which is distributed in tropical regions and many different areas in Saudi Arabia. A. hirtum is an economically and a medicinally useful plant in different zones of the world for healing various diseases. The current research explores the in vitro antioxidant characteristics and cytotoxic and genotoxic potential effects of the ethanolic leaf extract of A. hirtum (LEAH). Mitotic index (MI), micronucleus (MN), and chromosomal aberration (CA) tests were performed in Allium cepa, and MTT assays were performed using human dermal fibroblast, adult (HDFa) and breast cancer (MCF7) cell lines. The comet assay was used to assess the genotoxic effec

SUBMITTER: Qari SH 

PROVIDER: S-EPMC10407671 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature