Metabolic liver cancer: associations of rare and common germline variants in one-carbon metabolism and DNA methylation genes.

ABSTRACT: Animal studies implicate one-carbon metabolism and DNA methylation genes in hepatocellular carcinoma (HCC) development in the setting of metabolic perturbations. Using human samples, we investigated the associations between common and rare variants in these closely related biochemical pathways and risk for metabolic HCC development in a multicenter international study. We performed targeted exome sequencing of 64 genes among 556 metabolic HCC cases and 643 cancer-free controls with metabolic conditions. Multivariable logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for multiple comparisons. Gene-burden tests were used for rare variant associations. Analyses were performed in the overall sample and among non-Hispanic whites. The resul

SUBMITTER: Antwi SO 

PROVIDER: S-EPMC10407694 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature