Clonal hematopoiesis in older patients with breast cancer receiving chemotherapy.

ABSTRACT:

Background

The expansion of hematopoietic stem cells carrying recurrent somatic mutations, termed clonal hematopoiesis (CH), is common in elderly individuals and is associated with increased risk of myeloid malignancy and all-cause mortality. Though chemotherapy is a known risk factor for developing CH, how myelosuppressive therapies affect the short-term dynamics of CH remains incompletely understood. Most studies have been limited by retrospective design, heterogeneous patient populations, varied techniques to identifying CH, and analysis of single timepoints.

Methods

We examined serial samples from 40 older women with triple-negative or hormone receptor-positive breast cancer treated on the prospective ADjuVANt Chemotherapy in the Elderly trial to evaluate the prevalence

SUBMITTER: Mayerhofer C 

PROVIDER: S-EPMC10407695 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature