Genetic effects on molecular network states explain complex traits.

ABSTRACT: The complexity of many cellular and organismal traits results from the integration of genetic and environmental factors via molecular networks. Network structure and effect propagation are best understood at the level of functional modules, but so far, no concept has been established to include the global network state. Here, we show when and how genetic perturbations lead to molecular changes that are confined to small parts of a network versus when they lead to modulation of network states. Integrating multi-omics profiling of genetically heterogeneous budding and fission yeast strains with an array of cellular traits identified a central state transition of the yeast molecular network that is related to PKA and TOR (PT) signaling. Genetic variants affecting this PT state globally shifte

SUBMITTER: Weith M 

PROVIDER: S-EPMC10407735 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature