Scientific opinion on the tolerable upper intake level for vitamin D, including the derivation of a conversion factor for calcidiol monohydrate.

ABSTRACT: Following two requests from the European Commission (EC), the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the revision of the tolerable upper intake level (UL) for vitamin D and to propose a conversion factor (CF) for calcidiol monohydrate into vitamin D₃ for labelling purposes. Vitamin D refers to ergocalciferol (vitamin D₂), cholecalciferol (vitamin D₃), and calcidiol monohydrate. Systematic reviews of the literature were conducted to assess the relative bioavailability of calcidiol monohydrate versus vitamin D₃ on serum 25(OH)D concentrations, and for priority adverse health effects of excess vitamin D intake, namely persistent hypercalcaemia/hypercalciuria and endpoints related to

SUBMITTER: EFSA Panel on Nutrition, Novel Foods and FoodAllergens (NDA) 

PROVIDER: S-EPMC10407748 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature