Effects of Hypothermia vs Normothermia on Societal Participation and Cognitive Function at 6 Months in Survivors After Out-of-Hospital Cardiac Arrest: A Predefined Analysis of the TTM2 Randomized Clinical Trial.

ABSTRACT:

Importance

The Targeted Hypothermia vs Targeted Normothermia After Out-of-Hospital Cardiac Arrest (TTM2) trial reported no difference in mortality or poor functional outcome at 6 months after out-of-hospital cardiac arrest (OHCA). This predefined exploratory analysis provides more detailed estimation of brain dysfunction for the comparison of the 2 intervention regimens.

Objectives

To investigate the effects of targeted hypothermia vs targeted normothermia on functional outcome with focus on societal participation and cognitive function in survivors 6 months after OHCA.

Design, setting, and participants

This study is a predefined analysis of an international multicenter, randomized clinical trial that took place from November 2017 to January 2020 and included particip

SUBMITTER: Lilja G 

PROVIDER: S-EPMC10407762 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature