Immunoglobulin A Antibodies Against Myelin Oligodendrocyte Glycoprotein in a Subgroup of Patients With Central Nervous System Demyelination.

ABSTRACT:

Importance

Differential diagnosis of patients with seronegative demyelinating central nervous system (CNS) disease is challenging. In this regard, evidence suggests that immunoglobulin (Ig) A plays a role in the pathogenesis of different autoimmune diseases. Yet little is known about the presence and clinical relevance of IgA antibodies against myelin oligodendrocyte glycoprotein (MOG) in CNS demyelination.

Objective

To investigate the frequency of MOG-IgA and associated clinical features in patients with demyelinating CNS disease and healthy controls.

Design, setting, and participants

This longitudinal study comprised 1 discovery and 1 confirmation cohort derived from 5 centers. Participants included patients with suspected or confirmed demyelinating diseases and hea

SUBMITTER: Ayroza Galvao Ribeiro Gomes AB 

PROVIDER: S-EPMC10407763 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature