Ssa1-targeted antibody prevents host invasion by Candida albicans.

ABSTRACT:

Introduction

Candida albicans is a commensal fungus that colonizes most healthy individuals' skin and mucosal surfaces but can also cause life-threatening invasive infections, particularly in immunocompromised patients. Despite antifungal treatment availability, drug resistance is increasing, and mortality rates remain unacceptably high. Heat shock protein Ssa1, a conserved member of the Hsp70 family in yeast, is a novel invasin that binds to host cell cadherins, induces host cell endocytosis, and enables C. albicans to cause maximal damage to host cells and induces disseminated and oropharyngeal disease.

Result

Here we discovered a mouse monoclonal antibody (mAb 13F4) that targeting C. albicans Ssa1 with high affinity (EC₅₀ = 39.78 ng/mL). mA

SUBMITTER: Qiu XR 

PROVIDER: S-EPMC10407798 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature