Serum IgE levels are a risk factor with prognosis of pediatric minimal change disease.

ABSTRACT:

Background

Minimal change disease (MCD) is one of the most common primary glomerular disorders with high serum IgE levels. This study was aimed to investigate the clinical features of different serum IgE levels in pediatric MCD and evaluate the prognostic significance of serum IgE levels with regard to remission and relapse in pediatric cohort.

Methods

This study enrolled 142 new-onset children diagnosed with biopsy-proven MCD from January 2010 to December 2021 at the Jinling Hospital in Nanjing, China. These cases were divided into three groups according to serum IgE levels. MCD patients' demographics, clinical parameters, and follow-up data were collected and analyzed. The primary and secondary outcomes were defined as the time to the first complete remission (CR) and the

SUBMITTER: Han T 

PROVIDER: S-EPMC10407802 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature