A tabletability change classification system in supporting the tablet formulation design via the roll compaction and dry granulation process.

ABSTRACT: In this paper, the material library approach was used to uncover the pattern of tabletability change and related risk for tablet formulation design under the roll compaction and dry granulation (RCDG) process. 31 materials were fully characterized using 18 physical parameters and 9 compression behavior classification system (CBCS) parameters. Then, each material was dry granulated and sieved into small granules (125-250 μm) and large granules (630-850 μm), respectively. The compression behavior of granules was characterized by the CBCS descriptors, and were compared with that of ungranulated powders. The relative change of tabletability (CoT_r) index was used to establish the tabletability change classification system (TCCS), and all materials were classified into three ty

SUBMITTER: Su J 

PROVIDER: S-EPMC10407897 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature