Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [¹⁸F]UCB-H PET imaging.

ABSTRACT:

Objective

In preclinical research, the use of [¹⁸F]Fluorodesoxyglucose (FDG) as a biomarker for neurodegeneration may induce bias due to enhanced glucose uptake by immune cells. In this study, we sought to investigate synaptic vesicle glycoprotein 2A (SV2A) PET with [¹⁸F]UCB-H as an alternative preclinical biomarker for neurodegenerative processes in two mouse models representing the pathological hallmarks of Alzheimer's disease (AD).

Methods

A total of 29 PS2APP, 20 P301S and 12 wild-type mice aged 4.4 to 19.8 months received a dynamic [¹⁸F]UCB-H SV2A-PET scan (14.7 ± 1.5 MBq) 0-60 min post injection. Quantification of tracer uptake in cortical, cerebellar and brainstem target regions was implemented by calculating relative volumes of distri

SUBMITTER: Vogler L 

PROVIDER: S-EPMC10407951 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature