Protective effect of hydrogen sulfide is mediated by negative regulation of epigenetic histone acetylation in Parkinson's disease.

ABSTRACT:

Introduction

Derangements in monoaminergic transmission in the substantia nigra with disturbed signaling in the hypothalamic-pituitary-adrenal axis are the major characteristics of Parkinson's disease (PD). It has been reported that the administration of hydrogen sulfide (H₂S) is in practice to treat PD because of its redundant nature in regulating various neuronal signals. Hence, the current investigation was performed to evaluate the hypothesis that H₂S might exert protective action via the inhibition of epigenetic histone acetylation.

Material and methods

To test this notion, 6-hydroxydopamine (6-OHDA) was used to induce PD and sodium hydrogen sulfide (SHS) was used as a H₂S donor and tubastatin A (TSA) was tested in an in vivo rat

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10408026 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature