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A computational peptide model induces cancer cells' apoptosis by docking Kringle 5 to GRP78.

ABSTRACT:

Background

Cells can die through a process called apoptosis in both pathological and healthy conditions. Cancer development and progression may result from abnormal apoptosis. The 78-kDa glucose-regulated protein (GRP78) is increased on the surface of cancer cells. Kringle 5, a cell apoptosis agent, is bound to GRP78 to induce cancer cell apoptosis. Kringle 5 was docked to GRP78 using ClusPro 2.0. The interaction between Kringle 5 and GRP78 was investigated.

Results

The interacting amino acids were found to be localized in three areas of Kringle 5. The proposed peptide is made up of secondary structure amino acids that contain Kringle 5 interaction residues. The 3D structure of the peptide model amino acids was created using the PEP-FOLD3 web tool.

Conclusions

The proposed peptide completely binds to the GRP78 binding site on the Kringle 5, signaling that it might be effective in the apoptosis of cancer cells.

SUBMITTER: Khater I

PROVIDER: S-EPMC10408047 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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A computational peptide model induces cancer cells' apoptosis by docking Kringle 5 to GRP78.

Khater Ibrahim I Nassar Aaya A

BMC molecular and cell biology 20230808 1

<h4>Background</h4>Cells can die through a process called apoptosis in both pathological and healthy conditions. Cancer development and progression may result from abnormal apoptosis. The 78-kDa glucose-regulated protein (GRP78) is increased on the surface of cancer cells. Kringle 5, a cell apoptosis agent, is bound to GRP78 to induce cancer cell apoptosis. Kringle 5 was docked to GRP78 using ClusPro 2.0. The interaction between Kringle 5 and GRP78 was investigated.<h4>Results</h4>The interactin ...[more]

PMID: 37553635

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