Appraising the causal relationship between plasma caffeine levels and neuropsychiatric disorders through Mendelian randomization.

ABSTRACT:

Background

Caffeine exposure modifies the turnover of monoamine neurotransmitters, which play a role in several neuropsychiatric disorders. We conducted a Mendelian randomization study to investigate whether higher plasma caffeine levels are causally associated with the risk of anorexia nervosa, bipolar disorder, major depressive disorder (MDD), and schizophrenia.

Methods

Summary-level data on the neuropsychiatric disorders were obtained from large-scale genome-wide association studies (GWASs) of European ancestry participants (n = 72,517 to 807,553) and meta-analyzed with the corresponding data from the FinnGen study (n = 356,077). Summary-level data on plasma caffeine were extracted from a GWAS meta-analysis of 9876 European ancestry individuals. The Mendelian randomizatio

SUBMITTER: Woolf B 

PROVIDER: S-EPMC10408049 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature