Association between periodontitis and temporomandibular joint disorders.

ABSTRACT:

Background

Periodontitis (PD) may affect temporomandibular joint disorders (TMD) and TMD may influence PD in previous observational studies. Nevertheless, these studies were prone to confounders and reverse causation, leading to incorrect conclusions about causality and direction of association. This research investigates the associations between PD and TMD employing bidirectional two-sample Mendelian randomization (MR) analysis.

Methods

Single-nucleotide polymorphisms (SNPs) related to PD (p < 5 × 10^-6) were selected from a genome-wide association study (GWAS) from the Gene-Lifestyle Interaction in the Dental Endpoints (GLIDE) consortium, and related these to SNPs from FinnGen and UK Biobank (UKB) consortia, and vice versa. We implemented the standard inverse var

SUBMITTER: Wang S 

PROVIDER: S-EPMC10408055 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature