COVPRIG robustly predicts the overall survival of IDH wild-type glioblastoma and highlights METTL1⁺ neural-progenitor-like tumor cell in driving unfavorable outcome.

ABSTRACT:

Background

Accurately predicting the outcome of isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) remains hitherto challenging. This study aims to Construct and Validate a Robust Prognostic Model for IDH wild-type GBM (COVPRIG) for the prediction of overall survival using a novel metric, gene-gene (G × G) interaction, and explore molecular and cellular underpinnings.

Methods

Univariate and multivariate Cox regression of four independent trans-ethnic cohorts containing a total of 800 samples. Prediction efficacy was comprehensively evaluated and compared with previous models by a systematic literature review. The molecular underpinnings of COVPRIG were elucidated by integrated analysis of bulk-tumor and single-cell based datasets.

Results

Using a Cox-ph model

SUBMITTER: Ji H 

PROVIDER: S-EPMC10408096 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature