Systematic analysis of histone acetylation regulators across human cancers.

ABSTRACT:

Background

Histone acetylation (HA) is an important and common epigenetic pathway, which could be hijacked by tumor cells during carcinogenesis and cancer progression. However, the important role of HA across human cancers remains elusive.

Methods

In this study, we performed a comprehensive analysis at multiple levels, aiming to systematically describe the molecular characteristics and clinical relevance of HA regulators in more than 10000 tumor samples representing 33 cancer types.

Results

We found a highly heterogeneous genetic alteration landscape of HA regulators across different human cancer types. CNV alteration may be one of the major mechanisms leading to the expression perturbations in HA regulators. Furthermore, expression perturbations of HA regulators corr

SUBMITTER: Song C 

PROVIDER: S-EPMC10408135 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature