A stromal lineage maintains crypt structure and villus homeostasis in the intestinal stem cell niche.

ABSTRACT:

Background

The nutrient-absorbing villi of small intestines are renewed and repaired by intestinal stem cells (ISCs), which reside in a well-organized crypt structure. Genetic studies have shown that Wnt molecules secreted by telocytes, Gli1⁺ stromal cells, and epithelial cells are required for ISC proliferation and villus homeostasis. Intestinal stromal cells are heterogeneous and single-cell profiling has divided them into telocytes/subepithelial myofibroblasts, myocytes, pericytes, trophocytes, and Pdgfra^low stromal cells. Yet, the niche function of these stromal populations remains incompletely understood.

Results

We show here that a Twist2 stromal lineage, which constitutes the Pdgfra^low stromal cell and trophocyte subpopulations, mainta

SUBMITTER: Xiang J 

PROVIDER: S-EPMC10408166 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature