LC/MS-based untargeted lipidomics reveals lipid signatures of nonpuerperal mastitis.

ABSTRACT:

Background

Nonpuerperal mastitis (NPM) is a disease that presents with redness, swelling, heat, and pain during nonlactation and can often be confused with breast cancer. The etiology of NPM remains elusive; however, emerging clinical evidence suggests a potential involvement of lipid metabolism.

Method

Liquid chromatography‒mass spectrometry (LC/MS)-based untargeted lipidomics analysis combined with multivariate statistics was performed to investigate the NPM lipid change in breast tissue. Twenty patients with NPM and 10 controls were enrolled in this study.

Results

The results revealed significant differences in lipidomics profiles, and a total of 16 subclasses with 14,012 different lipids were identified in positive and negative ion modes. Among these lipids, trigl

SUBMITTER: Chen X 

PROVIDER: S-EPMC10408177 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature